ModaFlow™ : the first all-in-one benchtop instrument that integrates all the components to perform single-cell research based on droplet microfluidics easily.
Thanks to its fluorescence detector, droplet sorter and user-friendly software, ModaFlow makes functional cell sorting accessible to everyone.
Droplet microfluidics is a tremendous cutting-edge technology. It has the potential to screen millions of individual cells in one day and to find the rare and precious ones.
But if you have ever tried to set up a droplet microfluidic platform, you should know how much it is a Do-It -Yourself laborious work wich requires to assemble many technical components together: fluidics, optics, mechanics, electronics, software, ...
Henceforth, ModaFlow™ makes droplet microfluidics accessible to everyone with one single equipment.
It is equipped with the best optics allowing fluorescence detection with one up to three lasers and detectors, camera, high precision pressure pumps, pneumatic valves, a support for the microfluidic chip and its inlet and outlet reservoirs, and a proprietary all-in-one controlling software.
ModaFlow™ is particulary adapted to the realization of simple or complex workflows including single-cell manipulation: screening, mixing with reagents (drugs, antibodies, buffers, barcodes, … ), sorting, and one-to-one pairing.
ModaFlow™ is able to screen and sort cells individually, based on membranes or secreted proteins (functional screening), while preserving their viability.
High-throuhput : 150 000 cells sorted per hour.
Screening and sorting of biological cells, bacteria, exosomes, genetic content and particles.
Cell sorting based on intracellular or extracellular markers for functional analysis (secretome).
No dead volume, particularly adapted to precious cell samples.
Combination of up to six microfluidic modules to make your personalized workflows a reality.
Real time observation of the ongoing analysis.
ModaFlow™ instrument is modular and easy to use to perform a variety of workflows thanks to the combination of microfluidic chips and modules.
ModaFlow™ standard modules
- Single-cell encapsulation with reagents or particules
- Fluorescence screening (from 1 to 3 colors) and sorting
ModaFlow™ optional modules
- Reagent addition in droplets after incubation (e.g. lysis buffer)
- Incubation from 5’ to 48h
- Droplet digital PCR, thermocycling
- Sampling immobilization of shuffled or sampled content for quality check.
- Controlled pairing for co-encapsulation of two populations of cells or particles.
LiveDrop provides consumable microfluidic chips made of PDMS, embedded in a proprietary plug-and play cassette, ready to use on your ModaFlow™.
LiveDrop also delivers robust custom PDMS microfluidic chips designed for your specific needs.
These chips can be used with ModaFlow™, as well as with other microfluidic platforms.
LiveDrop has the know-how to produce multilayer PDMS microfluidic chips with embedded pneumatic valves for gentle cell sorting and droplet immobilization.